|
Reference
|
| Citation |
Bhadra, M.P., Mamatha, L., Bhadra, U. (2007). Tranposon born microRNAs in host-pathogen interaction. A. Dros. Res. Conf. 48 : 389B.
|
| FlyBase ID |
FBrf0198452 |
| Type of publication |
Abstract |
| Offprint Available |
No |
|
External Crossreferences
|
| PubMed ID |
|
| PubMed Abstract |
|
| Conference Abstract |
MicroRNAs are a family of tiny, endogenous 21-25 nt long non coding RNAs that control wide range of genes in various biological
processes. Here, small RNA profile of Drosophila embryos and adults recovered five novel microRNAs from Drosophila 1360 repetitive
element that initiates heterochromatin formation in Drosophila mini chromosome. The repression of miRNAs with concomitant
upregulation of hoppel activity is associated with mutational effect of RNAi components, piwi, Spindle E and Argonaute-1.
Accumulation of Pre-miRNA in piwi and Ago-1 heteroallelic mutations suggests that miRNAs function in RNA silencing pathway
and RNAi machinery is required for their biogenesis. They also participate as a convenient way for regulating multiple host
genes and hoppel transposon expression. These findings demonstrate an unexpected link between transposon born microRNAs and
host gene regulation. It is also postulated that despite of its role in heterochromatin, the importance of hoppel transposon
in host parasite interaction delimits its elimination from the Drosophila genome by the selective pressure of evolution.
|
| Biosis |
|
| Zoological record |
|
Associated Information
|
| Comments |
|
| Text of personal communication |
|
| Associated files |
|
|
Related Publications
|
|
|
|
Also Published As
|
|
|
|
Other Reference Information
|
| Secondary IDs |
|
| Language of publication |
English |
| Additional language(s) of abstract |
|
| ISBN |
|
| Place of publication |
|
|
Published In
|
| Abbreviation |
A. Dros. Res. Conf. 48 |
| Title |
Program and Abstracts. 48th Annual Drosophila Research Conference, Philadelphia, PA, 2007 |
| Authors |
|
| Volume range |
|
| Year range |
2007 |
| Page range |
|
| Publisher |
The Genetics Society of America |
| Place of publication |
Bethesda, MD |
| Language of publication |
English |
| ISBN/ISSN |
|
| CODEN |
|
|
Data from Reference
|
| Genes (3)
|
|
|
| Natural transposons (1)
|
|
|
|
Home