| Citation |
Kholodilov, N.G., Bolshakov, V.N., Blinov, V.M., Solovyov, V.V., Zhimulev, I.F. (1988). Intercalary heterochromatin in Drosophila. III. Homology between DNA sequences from the Y chromosome, bases of polytene chromosome limbs, and chromosome 4 of Drosophila
melanogaster. Chromosoma 97: 247--253.
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| PubMed Abstract |
Molecular and cytogenetic characteristics are given of a 2846 bp DNA sequence from the YDm12 clone, previously derived from
the long arm of the Drosophila melanogaster Y chromosome. Sequence analysis revealed within it a 1176 bp fragment with 37
bp terminal inverted repeats, flanked by 6 bp direct repeats. This fragment (called "element 1360") appeared to be A-T rich,
and was saturated with short direct and inverted repeats of different degrees of homology and consensus sequences for transcription,
potential Z-DNA transition and autonomous replication. After in situ hybridization to polytene chromosomes, the element 1360
exhibited variable, strain-specifics location in the euchromatic parts of the chromosome arms, but constant heavy labelling
of the X chromosome region 12E1-2, autosomal regions 42B1-3, 52A1-2, 62A1-2, 75B, 82C1-3, chromosome bases, the chromocentre
and numerous sites of chromosome 4. The possible role of element 1360 in heterochromatin organization is discussed.
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