Gene Dmel\lark

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General Information

Symbol

Dmel\lark

Species

D. melanogaster

Name

lark

Annotation symbol

CG8597

Feature type

protein_coding_gene

FlyBase ID

FBgn0011640

Created / Updated

2005-03-18/2005-03-18

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

65F5-65F5

Sequence location

3L:7,332,366..7,334,996 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol lark (CG8597, FBgn0011640). It has the cytological map location 65F5. Its sequence location is 3L:7332366..7334996. Its molecular function is described as: mRNA binding; RNA binding; zinc ion binding; nucleic acid binding; nucleotide binding. It is involved in the biological processes described with 11 unique terms, many of which group under: eclosion; circadian rhythm; multicellular organismal development; gamete generation; circadian behavior; sexual reproduction; embryonic development; locomotion; locomotory behavior; protein localization; actin filament-based process; ovarian nurse cell to oocyte transport. 25 alleles are reported. The phenotypes of these alleles are annotated with: wing; scutellar bristle; posterior scutellar bristle; embryo; adult cuticle. It has 5 annotated transcripts and 5 annotated polypeptides.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

65F5-65F5

Limits computationally determined from genome sequence between P{lacW}Cdc27^L7123 and P{EP}lark^EP3259&P{lacW}l(3)j1D5^j1D5

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

65E-65F

(Newby, 1996.5.29)

Experimentally Determined Recombination Data

Location

(Newby, 1996.5.29)

3-17.8

(Newby and Jackson, 1993)

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\lark for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

lark-RA

FBtr0076841

NM_079233

1832

352

lark-RB

FBtr0076842

NM_168202

1738

352

lark-RC

FBtr0076843

NM_168203

1779

352

lark-RD

FBtr0076844

NM_168204

1761

352

lark-RE

FBtr0076845

NM_168205

2082

352

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

lark-PA

FBpp0076552

39.9

352

9.30

NP_523957

AAF50578

lark-PB

FBpp0076553

39.9

352

9.30

NP_729237

AAN12053

lark-PC

FBpp0076554

39.9

352

9.30

NP_729238

AAN12054

lark-PD

FBpp0076555

39.9

352

9.30

NP_729239

AAN12055

lark-PE

FBpp0076556

39.9

352

9.30

NP_729240

AAN12056

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0011640

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

RNA recognition motif, RNP-1 (IPR000504)

Zinc finger, CCHC-type (IPR001878)

Nucleotide-binding, alpha-beta plait (IPR012677)

RNA binding motif 4 - LARK (IPR015466)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q94901

Maps to

Does NOT map to

Identified with

(Oliver, 2001.8.16)

LD40792

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

4935

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Microarray Data

Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)

Untitled Document detailed view

AI520594

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0011640

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0011640

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0011640

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal | recessive

lethal | embryonic stage | recessive

lark¹

lethal | pupal stage, with Scer\GAL4^Act5C.PHb

lark^{Scer\UAS.T:Ivir\HA1}

lethal | pharate adult stage, with Scer\GAL4^elav-C155

lark^{Scer\UAS.T:Ivir\HA1}

Other Phenotypes

Allele

wild-type

visible, with lark¹

visible, with lark^{ZF.T:Ivir\HA1}

lark¹

visible, with lark^{RRM2.RNP2.T:Ivir\HA1}

lark¹

visible, with lark^{RRM2+RTZF.T:Ivir\HA1}

lark¹

behavioral | dominant

lark¹

flight behavior defective, with lark¹

lark^{RRM2.RNP2.T:Ivir\HA1}

flight behavior defective, with lark^{RRM2.RNP2.T:Ivir\HA1}

lark¹

flightless, with lark¹

flightless, with lark^{ZF.T:Ivir\HA1}

lark¹

flightless, with lark^{RRM2+RTZF.T:Ivir\HA1}

lark¹

flightless, with lark^{RRM1+RTZF.T:Ivir\HA1}

lark¹

Sterility

Allele

female sterile, with lark¹

female sterile, with lark^{RRM2.RNP2.T:Ivir\HA1}

lark¹

female sterile, with lark^{RRM2+RTZF.T:Ivir\HA1}

lark¹

female sterile, with lark^{RRM1+RTZF.T:Ivir\HA1}

lark¹

male fertile, with lark¹

male fertile, with lark^{cMa.T:Ivir\HA1}

lark¹

male fertile, with lark^{RRM2.RNP2.T:Ivir\HA1}

lark¹

male fertile, with lark^{RRM2+RTZF.T:Ivir\HA1}

lark¹

male fertile, with lark^{RRM1.RNP2.T:Ivir\HA1}

lark¹

male fertile, with lark^{RRM1+RTZF.T:Ivir\HA1}

lark¹

female fertile, with lark¹

female fertile, with lark^{cMa.T:Ivir\HA1}

lark¹

female fertile, with lark^{RRM1.RNP2.T:Ivir\HA1}

lark¹

Phenotype manifest in

Allele

wing, with lark^{RRM2+RTZF.T:Ivir\HA1}

lark¹

scutellar bristle, with lark^{RRM2+RTZF.T:Ivir\HA1}

lark¹

posterior scutellar bristle, with lark^{ZF.T:Ivir\HA1}

lark¹

scutellar bristle | ectopic, with lark^{ZF.T:Ivir\HA1}

lark¹

scutellar bristle, with lark^{ZF.T:Ivir\HA1}

lark¹

wing, with lark^{ZF.T:Ivir\HA1}

lark¹

wing, with lark^{RRM2.RNP2.T:Ivir\HA1}

lark¹

scutellar bristle, with lark^{RRM2.RNP2.T:Ivir\HA1}

lark¹

embryo | germ-line clone

lark¹

wing, with lark¹

scutellar bristle, with lark¹

wing, with Scer\GAL4^elav-C155

lark^{Scer\UAS.T:Ivir\HA1}

adult cuticle, with Scer\GAL4^elav-C155

lark^{Scer\UAS.T:Ivir\HA1}

posterior scutellar bristle, with lark¹

lark^{ZF.T:Ivir\HA1}

scutellar bristle | ectopic, with lark¹

lark^{ZF.T:Ivir\HA1}

Classical Alleles ( 14 )

For All Classical Alleles Show

Allele of lark	Mutagen	Stocks	Known lesion
lark¹	Δ2-3 P-element activity	0	Yes
lark^DG23107	P-element activity	1	--
lark^EP3259	P-element activity	1	--
lark^EY00297	P-element activity	1	--
lark^EY23084	P-element activity	1	--
lark^R1	Δ2-3	0	Yes
lark^R2	Δ2-3	0	Yes
lark^R3	Δ2-3	0	Yes
lark^R4	Δ2-3	0	Yes
lark^R5	Δ2-3	0	Yes
lark^R6	Δ2-3	0	Yes
lark^a		0	--
lark^c01004	piggyBac transposase	1	--
lark^d04807	P-element activity	1	--

Alleles Carried on Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Allele of lark	Mutagen	Stocks	Known lesion
lark^+mMa	in vitro construct \| other	0	Yes
lark^GD1310	in vitro construct \| RNAi in vitro construct \| regulatory fusion	0	Yes
lark^{RRM1+2.RNP2.T:Ivir\HA1}	in vitro construct \| amino acid replacement	0	Yes
lark^{RRM1+RTZF.T:Ivir\HA1}	in vitro construct \| amino acid replacement	0	Yes
lark^{RRM1.RNP2.T:Ivir\HA1}	in vitro construct \| amino acid replacement	0	Yes
lark^{RRM2+RTZF.T:Ivir\HA1}	in vitro construct \| amino acid replacement	0	Yes
lark^{RRM2.RNP2.T:Ivir\HA1}	in vitro construct \| amino acid replacement	0	Yes
lark^{Scer\UAS.T:Ivir\HA1}	in vitro construct \| regulatory fusion	1	Yes
lark^{ZF.T:Ivir\HA1}	in vitro construct \| amino acid replacement in vitro construct \| coding region fusion	0	Yes
lark^{cMa.T:Ivir\HA1}	in vitro construct \| coding region fusion	0	Yes
lark^{ΔC.T:Ivir\HA1}	in vitro construct \| coding region fusion in vitro construct \| deletion	0	Yes

Aneuploid Aberrations

Useful deficiency