General Information
Symbol
Dmel\Cdc42
Species
D. melanogaster
Name
Cdc42
Annotation Symbol
CG12530
Feature Type
FlyBase ID
FBgn0010341
Gene Model Status
Stock Availability
Gene Snapshot
Cdc42 is a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. [Date last reviewed: 2016-06-30]
Also Known As
Dcdc42, DmCDC42
Genomic Location
Cytogenetic map
Sequence location
X:19,697,091..19,699,938 [+]
Recombination map
1-64
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Protein Family (UniProt, Sequence Similarities)
Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily. (P40793)
Molecular Function (see GO section for details)
Summaries
Gene Group Membership
RHO GTPASES -
Rho (Ras Homologous) GTPases are members of the Ras superfamily of small GTPases. They are best characterized for their roles in regulating actin organization. (Adapted from PMID:15731001).
Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependant manner. (Adapted from FBrf0222697 and FBrf0221727).
UniProt Contributed Function Data
Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions (PubMed:12490550). Together with mbt and Frl, regulates photoreceptor cell morphogenesis (PubMed:12490550, PubMed:26801180). Together with Frl, has a role in the neuronal development of mushroom bodies (PubMed:26801180).
(UniProt, P40793)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Cdc42 or the JBrowse view of Dmel\Cdc42 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.51
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.40
Gene model reviewed during 5.47
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0074751
1392
191
FBtr0309214
2078
191
FBtr0309215
2005
191
Additional Transcript Data and Comments
Reported size (kB)
2.3 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0074520
21.4
191
7.21
FBpp0301153
21.4
191
7.21
FBpp0301154
21.4
191
7.21
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

191 aa isoforms: Cdc42-PA, Cdc42-PC, Cdc42-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts with Frl (via GBD/FH3 domain); the interaction is stronger with the GTP bound form of Cdc42 (PubMed:26801180). The GTP-bound but not the GDP-bound form interacts with mbt and gek (PubMed:9371783, PubMed:12490550).
(UniProt, P40793)
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cdc42 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (70 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from physical interaction with FLYBASE:Whamy; FB:FBgn0037750
inferred from physical interaction with UniProtKB:Q9W1B0
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q9VXE5
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q9VUC6
(assigned by UniProt )
inferred from physical interaction with FLYBASE:mbt; FB:FBgn0025743
inferred from physical interaction with FLYBASE:Pak3; FB:FBgn0044826
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(assigned by GO_Central )
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(assigned by GO_Central )
inferred from sequence or structural similarity
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
Biological Process (54 terms)
Terms Based on Experimental Evidence (43 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Frl; FB:FBgn0267795
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Dys; FB:FBgn0260003
inferred from genetic interaction with FLYBASE:cv-c; FB:FBgn0285955
inferred from mutant phenotype
inferred from genetic interaction with UniProtKB:Q9VUC6
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (15 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000632904
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000632904
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000632904
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
traceable author statement
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(assigned by GO_Central )
Cellular Component (11 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from mutant phenotype
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
Expression Data
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Cdc42 is expressed in all developmental stages. It is expressed ubiquitously in embryos.
Cdc42 transcripts are detected throughout development. In embryos, strong ubiquitous expression is observed in blastoderm stages. The transcript is concentrated at the basal part of the cellular blastoderm. After gastrulation, transcripts become highly enriched in the somatic mesoderm. Transcripts start to appear in the CNS and gut in stage 13. Later, somatic mesoderm expression vanishes but gut and CNS expression persists.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from mutant phenotype
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cdc42 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 8 )
Transgenic Constructs ( 45 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cdc42
Allele of Cdc42
Mutagen
Associated Transgenic Construct
Stocks
Transgenic constructs containing regulatory region of Cdc42
characterization construct
Name
Expression Data
Deletions and Duplications ( 6 )
Summary of Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
abdominal posterior fascicle neuron & growth cone & filopodium, with Scer\GAL4elav.PLu
aCC neuron & dendrite, with Scer\GAL4eve.RN2
actin filament & rhabdomere | somatic clone
antenna & glial cell, with Scer\GAL4Mz317
antenna & sensory neuron, with Scer\GAL4Mz317
dorsal multidendritic neuron & dendrite & embryo, with Scer\GAL460
embryonic hemocyte & leading edge, with Scer\GAL4Pxn.PS, Scer\GAL4crq.PA
macrochaeta & metathoracic laterotergite, with Scer\GAL4Bx-MS1096
mesothoracic les3 neuron & growth cone & filopodium, with Scer\GAL4elav.PLu
metathoracic les3 neuron & growth cone & filopodium, with Scer\GAL4elav.PLu
microchaeta & metathoracic laterotergite, with Scer\GAL4Bx-MS1096
microchaeta & wing, with Scer\GAL4ptc-559.1
nurse cell & actin filament | germ-line clone | maternal effect
RP2 neuron & cell body, with Scer\GAL4eve.RN2
RP2 neuron & dendrite, with Scer\GAL4eve.RN2
RP2 neuron & neurite, with Scer\GAL4eve.RN2
tergal depressor of trochanter muscle motor neuron & dendrite, with Scer\GAL4shakB.lethal.4.1
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (21)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
 
3 of 15
No
No
 
3 of 15
No
No
 
3 of 15
No
No
3 of 15
No
Yes
2 of 15
No
No
2 of 15
No
Yes
1 of 15
No
No
 
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (19)
12 of 13
Yes
Yes
3 of 13
No
No
3 of 13
No
No
3 of 13
No
Yes
3 of 13
No
Yes
2 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (19)
10 of 12
Yes
Yes
3 of 12
No
No
2 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (39)
13 of 15
Yes
Yes
11 of 15
No
Yes
6 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
12 of 15
Yes
Yes
3 of 15
No
No
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (12)
5 of 9
Yes
No
5 of 9
Yes
No
5 of 9
Yes
No
5 of 9
Yes
No
5 of 9
Yes
No
5 of 9
Yes
No
5 of 9
Yes
No
5 of 9
Yes
No
5 of 9
Yes
Yes
4 of 9
No
No
4 of 9
No
No
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (6)
14 of 15
Yes
Yes
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
12 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190FXQ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150BEP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0D88 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0CS8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0KCM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Human Disease Model Data
FlyBase Human Disease Model Reports
Alleles Reported to Model Human Disease (Disease Ontology)
Download
Models ( 2 )
Allele
Disease
Evidence
References
model of  cancer
model of  kidney disease
inferred from mutant phenotype
Interactions ( 0 )
Allele
Disease
Interaction
References
Comments ( 0 )
 
Human Orthologs (via DIOPT v7.1)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please look at the Interaction Group reports for full details of the physical interactions
protein-protein
Interacting group
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Interacts with Frl (via GBD/FH3 domain); the interaction is stronger with the GTP bound form of Cdc42 (PubMed:26801180). The GTP-bound but not the GDP-bound form interacts with mbt and gek (PubMed:9371783, PubMed:12490550).
(UniProt, P40793 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Pathways
Gene Group - Pathway Membership (FlyBase)
Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependant manner. (Adapted from FBrf0222697 and FBrf0221727).
External Data
Genomic Location and Detailed Mapping Data
Chromosome (arm)
X
Recombination map
1-64
Cytogenetic map
Sequence location
X:19,697,091..19,699,938 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
18E1-18E1
Limits computationally determined from genome sequence between P{EP}Sec61γEP1511 and P{EP}EP1116&P{EP}EP1344EP1344
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
18E-18E
(determined by in situ hybridisation)
18D-18D
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (31)
Genomic Clones (9)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (187)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
 
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of
Source for database merge of
Additional comments
The Rac2 gene may have been derived from the Cdc42 gene by retroposition.
Other Comments
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
Identified in an RNAi screen for host factors that alter infection of SL2 cells by L.monocytogenes.
Identified in an RNAi screen for host factors that alter infection of SL2 cells by M.fortuitum.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi generated by PCR using primers directed to this gene causes a cell shape change from round to polarized when assayed in Kc167 cells, with the formation of F-actin puncta and microtubule extensions. For both Kc167 and S2R+ cells, reduced F-actin and altered cell shape occur.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
Cdc42 appears to be required for the regulation of actin polymerisation and/or myosin activity that is critical for the response of growth cones to midline repulsive signals.
Cdc42 is necessary for cellular extenion formation, but not for actin cable formation during wound healing in the embryo.
Cdc42 may be a negative regulator of N signalling.
Cdc42 has a role in actin filament assembly and plays a role on intercellular interactions between the germ-line and the somatic follicle cells.
Cdc42, but not Rac1, is an activator of puc expression in a hep dependent manner in imaginal discs.
Cdc42 has a function in dendritic development.
ISNb growth cones require Cdc42 for extension to appropriate targets.
Cdc42 is not allelic to btdl.
Rac1 and Cdc42 are components of the bsk pathway and are upstream activators of hep and dpp.
Cdc42, RhoL and Rac1 protein activities are required for normal transfer of cytoplasm from nurse cells to the oocyte.
Comparison of expression of constitutively active or dominantly negative Cdc42 and Rac1 mutants demonstrates that similar GTPases in the same subfamily have unique roles in morphogenesis in vivo.
Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 75 )
Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Linkouts
BioGRID - A database of protein and genetic interactions.
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
FlyMine - An integrated database for Drosophila genomics
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
KEGG Genes - Molecular building blocks of life in the genomic space.
modMine - A data warehouse for the modENCODE project
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Synonyms and Secondary IDs (18)
Reported As
Symbol Synonym
Cdc42
(Carmena, 2018, Medina, 2018, Saito et al., 2018, Schmidt and Grosshans, 2018, Spinner et al., 2018, Tsai et al., 2018, Banisch et al., 2017, Colombié et al., 2017, Couturier et al., 2017, Davis and Zhong, 2017, Lou et al., 2017, Nakamura et al., 2017, Ozasa et al., 2017, Park et al., 2017, Siddall and Hime, 2017, Ajduk and Zernicka-Goetz, 2016, Brinkmann et al., 2016, Carvajal-Gonzalez et al., 2016, Dollar et al., 2016, Fear et al., 2016, Matsubayashi and Millard, 2016, Meehan et al., 2016, Roman-Fernandez and Bryant, 2016, Sarov et al., 2016, Schimizzi et al., 2016, Whitney et al., 2016, Flores-Benitez and Knust, 2015, Gombos et al., 2015, Grotewiel and Bettinger, 2015, Morán et al., 2015, Ojelade et al., 2015, Ojelade et al., 2015, Petsakou et al., 2015, Rosa et al., 2015, Verboon and Parkhurst, 2015, Verboon et al., 2015, Vlisidou and Wood, 2015, Abreu-Blanco et al., 2014, Iordanou et al., 2014, Jones et al., 2014, Lammel et al., 2014, Pichaud, 2014, Sailem et al., 2014, Sharifai et al., 2014, Swope et al., 2014, Yashiro et al., 2014, Beckett et al., 2013, Bergstralh et al., 2013, Chen et al., 2013, Leibfried et al., 2013, Melzer et al., 2013, Muha and Müller, 2013, Neisch et al., 2013, Puram and Bonni, 2013, Schertel et al., 2013, Sopko and Perrimon, 2013, Zhang et al., 2013, Zhang et al., 2013, Zhu, 2013, Abreu-Blanco et al., 2012, Baek et al., 2012, Fabian and Brill, 2012, Gates, 2012, Howell et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jean et al., 2012, Jeon et al., 2012, Murray et al., 2012, Peltan et al., 2012, Peru Y Colón de Portugal et al., 2012, Reed et al., 2012, Sampson and Williams, 2012, Sampson et al., 2012, Tepass, 2012, Tsubouchi et al., 2012, Zoller and Schulz, 2012, Fauvarque and Williams, 2011, Gontang et al., 2011, Jones and Metzstein, 2011, Meiklejohn et al., 2011, Muyskens and Guillemin, 2011, Nahm and Lee, 2011, Pilgram et al., 2011, Qian et al., 2011, Razzell et al., 2011, Rotkopf et al., 2011, Song and Giniger, 2011, Tanaka et al., 2011, Zhang et al., 2011, Baek et al., 2010, Ball et al., 2010, Colinet et al., 2010, Colosimo et al., 2010, D'Ambrosio and Vale, 2010, Dorsten et al., 2010, Elsaesser et al., 2010, Garlena et al., 2010, Georgiou and Baum, 2010, Nahm et al., 2010, Neisch et al., 2010, Pirraglia et al., 2010, Popodi et al., 2010-, Quinones et al., 2010, Robinson et al., 2010, Sato et al., 2010, Shim et al., 2010, Siekhaus et al., 2010, Venken et al., 2010, Walther and Pichaud, 2010, Warner, 2010.9.15, Warner et al., 2010, Asano et al., 2009, Frank et al., 2009, Fricke et al., 2009, Gupta et al., 2009, Hirano et al., 2009, Kamiyama and Chiba, 2009, Liu et al., 2009, Patch et al., 2009, van Impel et al., 2009, Warner and Cook, 2009.11.19, Warner and Longmore, 2009, Warner and Longmore, 2009, Bakal et al., 2008, Harris and Tepass, 2008, Harris and Tepass, 2008, Kim et al., 2008, Larson et al., 2008, Ng, 2008, Pielage et al., 2008, Qin et al., 2008, Rodal et al., 2008, Vogler et al., 2008, Warren-Paquin et al., 2008, Zhou et al., 2008, Atwood et al., 2007, Bakal et al., 2007, Bakal et al., 2007, Beltran et al., 2007, Colinet et al., 2007, Derré et al., 2007, Dorsten et al., 2007, Garcia-Mata and Burridge, 2007, Jovceva et al., 2007, Leibfried et al., 2007, Muñoz-Descalzo et al., 2007, Taniguchi et al., 2007, Tepass and Harris, 2007, Williams and Hultmark, 2007, Williams et al., 2007, Hozumi et al., 2006, Humbert et al., 2006, Kerkhoff, 2006, Nahm et al., 2006, Rothenfluh et al., 2006, Sanny et al., 2006, Srahna et al., 2006, Stroschein-Stevenson et al., 2006, Suzuki and Ohno, 2006, Talbot and VanBerkum, 2006, Avet-Rochex et al., 2005, Cho et al., 2005, Go, 2005, Sen et al., 2005, Stramer et al., 2005, Wiggin et al., 2005, Hofmann et al., 2004, Hutterer et al., 2004, Matsuura et al., 2004, Paladi and Tepass, 2004, Raymond et al., 2004, Gao and Bogert, 2003, Rogers et al., 2003, Kim et al., 2002, Wolf et al., 2002)
D-Cdc42
Dm Cdc42
Secondary FlyBase IDs
  • FBgn0012059
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
References (510)