General Information
Symbol
Dmel\bab1
Species
D. melanogaster
Name
bric a brac 1
Annotation Symbol
CG9097
Feature Type
FlyBase ID
FBgn0004870
Gene Model Status
Stock Availability
Gene Snapshot
Bric a brac 1 (Bab1) is a transcriptional regulator that functions partially redundantly with bab2. Bab1 is part of the conserved proximal-distal gene regulatory network module. Bab1 contributes to pattern formation, ovary morphogenesis, abdominal pigmentation and olfactory receptor neuron fate diversity. [Date last reviewed: 2016-06-23]
Also Known As
bab, bab-I, bric-a-brac
Genomic Location
Cytogenetic map
Sequence location
3L:1,036,369..1,101,089 [-]
Recombination map
3-0.5
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Molecular Function (see GO section for details)
Experimental Evidence
Predictions / Assertions
Summaries
Gene Group Membership
PIPSQUEAK TRANSCRIPTION FACTORS -
Pipsqueak transcription factors are sequence-specific DNA binding proteins that regulate transcription. These family members are characterized by a heix-turn-helix DNA-binding domain called Psq domain, which consists of four tandem repeats of a conserved 50-amino acid sequence, the Psq motif. (Adapted from FBrf0148954 and FBrf0105267).
UniProt Contributed Function Data
Probably acts as a transcriptional regulator. Required for the specification of the tarsal segment. Also involved in antenna development.
(UniProt, Q9W0K7)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the GBrowse view of Dmel\bab1 or the JBrowse view of Dmel\bab1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.53
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0072642
5340
977
FBtr0333268
5319
970
FBtr0333269
5322
971
FBtr0333270
5337
976
Additional Transcript Data and Comments
Reported size (kB)
5.4 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0072538
103.3
977
8.25
FBpp0305466
102.6
970
8.25
FBpp0305467
102.7
971
8.25
FBpp0305468
103.3
976
8.25
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
May form dimers.
(UniProt, Q9W0K7)
Crossreferences
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bab1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (16 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from physical interaction with FLYBASE:bip2; FB:FBgn0026262
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
Biological Process (12 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from expression pattern
(assigned by UniProt )
inferred from expression pattern
(assigned by UniProt )
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:abd-A; FB:FBgn0000014
inferred from genetic interaction with FLYBASE:Abd-B; FB:FBgn0000015
Terms Based on Predictions or Assertions (9 terms)
CV Term
Evidence
References
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001135010
(assigned by GO_Central )
Expression Data
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

Additional Descriptive Data
Transcript expression in the ovary is restricted to the cells that form the terminal filaments. Transcript is expressed in the primordium of tarsal segments TS1-TS4 in leg imaginal discs.
Within the leg imaginal disc, the bab transcript is detected in the primordia for tarsal segments 2 to 4 and the distal margin of tarsal segment 1.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Two cis regulatory elements govern bab1 expression in the pupal abdomen: one element that regulates bab1 expression in segments A2–A4 of both sexes and a second, dimorphic element that regulates expression in the posterior segments A5–A7 of females.
The bab protein is located in the nucleus.
Starting in larval mid-third instar, lacZ expression is detected in a concentric domain in leg and antennal imaginal discs. These expression domains correspond to the primordia of the tarsus, and subdistal structures of the antenna, respectively. By late third larval instar, expression is stronger, and the primordia of tarsal segments 2 to 4, and of the distal portion of tarsal segment 1, are stained. The expression displays a graded and wave-like pattern: tarsal folds 3 and 4 stain more than folds 1 and 2, and the ridges of the folds stain more than the furrows. This staining pattern is still visible in 6 hour-old prepupae. In adults, staining is seen in two segments of the antennal basal cylinder.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
Expression Deduced from Reporters
Reporter: P{A92}bab1A30
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{A92}bab1P
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GawB}bab1Agal4-5
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GawB}bab1Gal4
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GawB}bab1Pgal4-2
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GawB}bab1
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\bab1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 35 )
For All Classical and Insertion Alleles Show
 
Allele of bab1
Class
Mutagen
Associated Insertion
Stocks
Known lesion
    0
    --
    Other relevant insertions
    Transgenic Constructs ( 9 )
    Deletions and Duplications ( 9 )
    Summary of Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Lethality
    Allele
    Sterility
    Allele
    Other Phenotypes
    Allele
    Phenotype manifest in
    Allele
    Orthologs
    Human Orthologs (via DIOPT v7.1)
    Homo sapiens (Human) (2)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Alignment
    Complementation?
    Transgene?
    2 of 15
    Yes
    Yes
    2 of 15
    Yes
    Yes
    Model Organism Orthologs (via DIOPT v7.1)
    Mus musculus (laboratory mouse) (2)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Alignment
    Complementation?
    Transgene?
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    Rattus norvegicus (Norway rat) (2)
    1 of 13
    Yes
    No
    1 of 13
    Yes
    No
    Xenopus tropicalis (Western clawed frog) (2)
    1 of 12
    Yes
    Yes
    1 of 12
    Yes
    Yes
    Danio rerio (Zebrafish) (3)
    1 of 15
    Yes
    No
    1 of 15
    Yes
    Yes
    1 of 15
    Yes
    Yes
    Caenorhabditis elegans (Nematode, roundworm) (1)
    1 of 15
    Yes
    Yes
    Arabidopsis thaliana (thale-cress) (0)
    No orthologs reported.
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    No orthologs reported.
    Schizosaccharomyces pombe (Fission yeast) (0)
    No orthologs reported.
    Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091904IH )
    Organism
    Common Name
    Gene
    AAA Syntenic Ortholog
    Multiple Dmel Genes in this Orthologous Group
    Drosophila melanogaster
    fruit fly
    Drosophila suzukii
    Spotted wing Drosophila
    Drosophila simulans
    Drosophila sechellia
    Drosophila sechellia
    Drosophila erecta
    Drosophila yakuba
    Drosophila ananassae
    Drosophila pseudoobscura pseudoobscura
    Drosophila persimilis
    Drosophila persimilis
    Drosophila willistoni
    Drosophila virilis
    Drosophila mojavensis
    Drosophila grimshawi
    Drosophila grimshawi
    Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505F0 )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Musca domestica
    House fly
    Lucilia cuprina
    Australian sheep blowfly
    Mayetiola destructor
    Hessian fly
    Mayetiola destructor
    Hessian fly
    Mayetiola destructor
    Hessian fly
    Aedes aegypti
    Yellow fever mosquito
    Anopheles gambiae
    Malaria mosquito
    Culex quinquefasciatus
    Southern house mosquito
    Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03II )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Bombyx mori
    Silkmoth
    Danaus plexippus
    Monarch butterfly
    Danaus plexippus
    Monarch butterfly
    Danaus plexippus
    Monarch butterfly
    Heliconius melpomene
    Postman butterfly
    Heliconius melpomene
    Postman butterfly
    Apis florea
    Little honeybee
    Apis florea
    Little honeybee
    Apis florea
    Little honeybee
    Apis florea
    Little honeybee
    Apis mellifera
    Western honey bee
    Apis mellifera
    Western honey bee
    Bombus impatiens
    Common eastern bumble bee
    Bombus impatiens
    Common eastern bumble bee
    Bombus terrestris
    Buff-tailed bumblebee
    Linepithema humile
    Argentine ant
    Linepithema humile
    Argentine ant
    Megachile rotundata
    Alfalfa leafcutting bee
    Megachile rotundata
    Alfalfa leafcutting bee
    Megachile rotundata
    Alfalfa leafcutting bee
    Nasonia vitripennis
    Parasitic wasp
    Nasonia vitripennis
    Parasitic wasp
    Dendroctonus ponderosae
    Mountain pine beetle
    Dendroctonus ponderosae
    Mountain pine beetle
    Dendroctonus ponderosae
    Mountain pine beetle
    Tribolium castaneum
    Red flour beetle
    Tribolium castaneum
    Red flour beetle
    Pediculus humanus
    Human body louse
    Pediculus humanus
    Human body louse
    Pediculus humanus
    Human body louse
    Rhodnius prolixus
    Kissing bug
    Rhodnius prolixus
    Kissing bug
    Cimex lectularius
    Bed bug
    Acyrthosiphon pisum
    Pea aphid
    Acyrthosiphon pisum
    Pea aphid
    Acyrthosiphon pisum
    Pea aphid
    Acyrthosiphon pisum
    Pea aphid
    Acyrthosiphon pisum
    Pea aphid
    Acyrthosiphon pisum
    Pea aphid
    Acyrthosiphon pisum
    Pea aphid
    Acyrthosiphon pisum
    Pea aphid
    Acyrthosiphon pisum
    Pea aphid
    Acyrthosiphon pisum
    Pea aphid
    Acyrthosiphon pisum
    Pea aphid
    Zootermopsis nevadensis
    Nevada dampwood termite
    Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0ABC )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Strigamia maritima
    European centipede
    Strigamia maritima
    European centipede
    Ixodes scapularis
    Black-legged tick
    Ixodes scapularis
    Black-legged tick
    Ixodes scapularis
    Black-legged tick
    Stegodyphus mimosarum
    African social velvet spider
    Tetranychus urticae
    Two-spotted spider mite
    Daphnia pulex
    Water flea
    Daphnia pulex
    Water flea
    Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0WNB )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Strongylocentrotus purpuratus
    Purple sea urchin
    Strongylocentrotus purpuratus
    Purple sea urchin
    Ciona intestinalis
    Vase tunicate
    Human Disease Model Data
    FlyBase Human Disease Model Reports
      Alleles Reported to Model Human Disease (Disease Ontology)
      Download
      Models ( 0 )
      Allele
      Disease
      Evidence
      References
      Interactions ( 0 )
      Allele
      Disease
      Interaction
      References
      Comments ( 0 )
       
      Human Orthologs (via DIOPT v7.1)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      Complementation?
      Transgene?
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Interactions Browser
      Summary of Genetic Interactions
      esyN Network Diagram
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Subunit Structure (UniProtKB)
      May form dimers.
      (UniProt, Q9W0K7 )
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      Pathways
      Gene Group - Pathway Membership (FlyBase)
      External Data
      Linkouts
      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3L
      Recombination map
      3-0.5
      Cytogenetic map
      Sequence location
      3L:1,036,369..1,101,089 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      61E2-61F1
      Limits computationally determined from genome sequence between P{PZ}l(3)0596705967 and P{PZ}l(3)0264002640
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      61F1-61F3
      (determined by in situ hybridisation)
      Experimentally Determined Recombination Data
      Location
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (24)
      Genomic Clones (47)
      cDNA Clones (36)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequences
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for database merge of
          Source for merge of: bab1 anon-WO0118547.639
          Source for merge of: bab CG13910
          Additional comments
          "fap" (female abdomen pattern) is very likely to correspond to the "bab" locus (which is composed of the paralogous "bab1" and "bab2" genes).
          Annotations CG9097 and CG13910 merged as CG9097 in release 3 of the genome annotation.
          Source for merge of bab1 anon-WO0118547.639 was sequence comparison ( date:051113 ).
          Other Comments
          DNA-protein interactions: genome-wide binding profile assayed for bab1 protein in 0-12 hr embryos; see mE1_TFBS_bab1 collection report.
          bab1 and bab2 are both required for normal development. The functions of bab1 and bab2 show both redundant and divergent aspects, with bab2 playing a predominant role in exerting "bab" function. Both bab1 and bab2 are required for normal ovarian development, but loss-of-function of bab2 causes a more severe ovarian phenotype. There is an overlapping but differential requirement for bab1 and bab2 in the pigmentation of different adult abdominal segments, with A7 being more dependent on bab1 and A5 being more dependent on bab2 activity. Only bab2 plays an essential role in leg development; a bab1 mutant does not cause a mutant leg phenotype, whereas even weak bab2 mutants show leg defects. The strongest defects in ovaries, legs and abdomen that are associated with the "bab" locus are only seen in mutants that are null for both bab1 and bab2.
          Pigmentation patterns specified by bab1 affect mating preferences, suggesting that sexual selection has contributed to the evolution of bab1 regulation.
          bab1 expression is modulated segment- and sex-specifically in sexually dimorphic species but is uniform in sexually monomorphic species.
          bab1 integrates regulatory inputs from the homeotic and sex-determination pathways to control sexually dimorphic abdominal pigmentation and segment morphology.
          bab1 is required for the formation of the terminal filaments in the third larval instar ovary. The N terminal region of the protein encodes for a regulator of gene expression that contains the BTB domain.
          bab1 is cell autonomously required for the formation of terminal filaments and is crucial for the normal morphogenesis of the ovary.
          bab1 is necessary for terminal filament cluster formation which is required in turn for ovariole morphogenesis to take place.
          bab1 function is dosage-dependent and is required in a graded manner for the specification of tarsal segments. This and its expression pattern suggests that bab1 function may specify segment identity in the tarsus. Strong mutants and deletions for bab1 show a temperature-sensitive haploinsufficient dominant phenotype.
          Mutations in bab1 disrupt the formation of the terminal filaments in larval ovaries and cause severe disorganised adult ovaries. bab1 has been cloned and shown to be expressed in the terminal filament cells.
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 56 )
          Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMine - An integrated database for Drosophila genomics
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          Synonyms and Secondary IDs (20)
          Reported As
          Symbol Synonym
          CG13910
          anon-WO0118547.639
          Secondary FlyBase IDs
          • FBgn0035183
          • FBgn0061802
          Datasets (1)
          Study focus (1)
          Experimental Role
          Project
          Project Type
          Title
          • bait_protein
          Genome-wide localization of transcription factors by ChIP-chip and ChIP-Seq.
          References (189)