General Information
Symbol
Dmel\sicilyUAS.cZa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Zhang
FlyBase ID
FBal0284117
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-sicily
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UAS regulatory sequences drive expression of the sicily coding sequence (derived from the RE44923 cDNA clone).
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Model Data
Disease Ontology
Models ( 0 )
Disease
Evidence
References
Interactions ( 1 )
Disease
Interaction
References
DOES NOT ameliorate  Parkinson's disease
Comments ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Ubiquitous expression of sicilyScer\UAS.cZa under the control of Scer\GAL4da.PU restores climbing and flight ability in Pink1B9 mutant flies. Flight muscle and mitochondrial integrity are only partially restored. Expression of sicilyScer\UAS.cZa under the control of Scer\GAL4da.PU rescues the reduction in complex I seen in Pink1B9 mutant flies, but ATP levels are not significantly increased. Ubiquitous expression of sicilyScer\UAS.cZa under the control of Scer\GAL4da.PU does not rescue the climbing and flight defects seen in park25 mutant flies. The flight muscle and mitochondrial integrity defects are also not rescued. Expression of sicilyScer\UAS.cZa under the control of Scer\GAL4da.PU does not rescue the reduction in complex I and ATP levels seen in park25 mutant flies.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
sicilyScer\UAS.cZa
sicilyUAS.cZa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Zhang
Secondary FlyBase IDs
    References (3)