General Information
Symbol
Dmel\CAP49e
Species
D. melanogaster
Name
FlyBase ID
FBal0282652
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:
2973 kb deletion resulting from the imprecise excision of P{PTT-GA}CAPCA06924.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference
Imprecise excision of the progenitor insertion, resulting in a 2972bp deletion (coordinates 2R:6190378 ..6193350, release 5 genome) that removes the first two SH3 domain-coding exons.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Model Data
Disease Ontology
Models ( 0 )
Disease
Evidence
References
Interactions ( 0 )
Disease
Interaction
References
Comments ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Homozygous and hemizygous larvae do not show a significant hunching response to vibration, in contrast to wild-type controls. The electrophysiological response of the auditory nerve to mating songs is significantly reduced in homozygous adults compared to wild type. Mutant scolopale cells of the Johnston's organ are dysmorphic and appear collapsed and ruptured. In addition the Johnston's organ sensory neurons often show accumulation of vacuolar structures. Actin organisation at the muscle attachment site (MAS) between lateral-ventral somatic muscles 6 and 7 in abdominal segments is severely disrupted in mutant larvae, resulting in a jagged boundary. There is a significantly enlarged gap between actin filaments from adjacent muscles at most MASs. Larger junctional invaginations are seen at the mutant MAS than in wild type and integrin distribution is broader than normal. Aberrant muscle structure, with Z-lines oriented perpendicular to the MAS, is seen in approximately 30% of larvae. The parallel arrangement of actomyosin filaments is disrupted close to the muscle membrane in approximately 15% of larvae. MASs of lateral transverse muscles appear normal.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Expression of CAPC.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Mef2.PR fully rescues the muscle attachment defects of CAP49e mutant larvae. Expression of CAPΔSoHo.C.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Mef2.PR rescues the muscle attachment defects of CAP49e mutant larvae. Expression of CAPE.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Mef2.PR fails to rescue the muscle attachment defects of CAP49e mutant larvae.
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CAP49e
Name Synonyms
Secondary FlyBase IDs
    References (1)