General Information
Symbol
Dmel\Lpt1
Species
D. melanogaster
Name
FlyBase ID
FBal0268746
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
cmi1
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:
Inferred boundaries of a ~500 bp deletion resulting from the imprecise excision of P{EPgy2}EY06424, which includes the region upstream of Lpt as well as 61 bp of coding sequence.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference
Excision of P{EPgy2}EY06424 resulting in a ~500bp deletion that includes the Lpt promoter and 61bp of the Lpt open reading frame. No Lpt is detectable in homozygotes.
Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Model Data
Disease Ontology
Models ( 0 )
Disease
Evidence
References
Interactions ( 0 )
Disease
Interaction
References
Comments ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Homozygous lethal, with the majority of mutants failing to survive beyond the second or early third larval instar stages. Many of the dying larvae retain larval mouth hooks from the L2 molt, and in some cases L2 and L3 mouth hooks are malformed, indicating a defect in cuticle shedding. Mutant larvae exhibit sluggish movement, even though they retain normal olfactory functions, touch sensitivity and phototaxis. Feeding mutant larvae with ecdysone does not affect these phenotypes. Homozygous mutants eventually stop moving and appear to attempt pupariation. However, they fail to evert their spiracles and frequently turn brown but never produce a pupal cuticle. Many larvae develop interior necrotic patches, suggestive of larval hematopoiesis defects.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Lpt1/Lpt[+] is an enhancer of visible phenotype of dppd-ho/dpps1
Lpt1/Lpt[+] is an enhancer of visible phenotype of dpps1
Other
Statement
Reference
Lpt1/Lpt[+], dpps1 has visible phenotype
Phenotype Manifest In
Enhancer of
Statement
Reference
Lpt1/Lpt[+] is an enhancer of posterior crossvein phenotype of dppd-ho/dpps1
Lpt1/Lpt[+] is an enhancer of wing vein L4 phenotype of dpps1
Lpt1/Lpt[+] is an enhancer of posterior crossvein phenotype of dpps1
Lpt1 is an enhancer of eye phenotype of B1
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Approximately 4% of trans-heterozygous dpps1/Lpt1 flies show a shortened posterior crossvein. When dpps1 is homozygous, Lpt1/+ flies display shortened L4, and occasionally, L2 wing veins, in addition to the enhancement of the posterior crossvein phenotype. Approximately 6% of flies trans-heterozygous for Lpt1/dpps1 dppd-ho display a shortened posterior crossvein. Lpt1/+ flies homozygous for both dpps1 and dppd-ho show enhancement of the posterior crossvein phenotype relative to trans-heterozygotes, and shortened L2 and L4 veins.
Flies that are heterozygous for Lpt1 and also heterozygous for EcRA483T, or hemizygous for trr4, have defects in wing patterning - most prominently, shortened veins. Lpt1/+ strongly enhances the reduced eye phenotype of B1/+ flies.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Expression of LptScer\UAS.T:Ivir\HA1 under Scer\GAL4 control restores viability to Lpt1/Df(2R)or-BR11 animals.
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)