General Information
Symbol
Dmel\Ca-α1Tdel
Species
D. melanogaster
Name
FlyBase ID
FBal0267504
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:
Scer\FRT-mediated recombination between the two progenitor insertions has deleted the sequence between them, and produced a hybrid residual element.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference
Scer\FRT-mediated recombination between the two progenitor insertions has deleted the intervening sequence between them, and produced a hybrid residual element.
Insertion components
PBac{WHr}Ca-α1Tdel
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Model Data
Disease Ontology
Models ( 0 )
Disease
Evidence
References
Interactions ( 0 )
Disease
Interaction
References
Comments ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Ca-α1Tdel mutant males and females show a significantly decreased lifespan compared to controls; males, but not females, also show a less severe age-dependent decline in locomotion, as compared to controls. Ca-α1Tdel mutants show decreased cardiac function, as shown by the significant decrease in heart rate, end diastolic diameter and arrhythmic index, but not in fractional shortening or end systolic diameter, as compared to controls.
Adult MN5 neurons show multiple calcium current phenotypes in mutant animals. In 56% of animals both the transient low voltage activated (LVA) and the sustained high voltage activated (HVA) calcium currents are completely abolished, in 28% of cases LVA and HVA calcium currents with reduced amplitudes are seen, and in the remaining 16% of cases the calcium currents of the MN5 neuron appear similar to those of control animals.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Suppressor of
Statement
Reference
Ca-α1Tdel is a non-suppressor of neurophysiology defective phenotype of Ihf03355
Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Expression of cacScer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4103.3 in a Ca-α1Tdel background results in low voltage activated, maximum total calcium current and sustained high voltage activated calcium currents with normal activation voltages but reduced amplitudes compared to controls in the adult MN5 neuron.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Ca-α1Tdel
Name Synonyms
Secondary FlyBase IDs
    References (3)