General Information
Symbol
Dmel\thoc51
Species
D. melanogaster
Name
FlyBase ID
FBal0263654
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    An in frame deletion of 255 bp in exon 5 of thoc5.
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Model Data
    Disease Ontology
    Models ( 0 )
    Disease
    Evidence
    References
    Interactions ( 0 )
    Disease
    Interaction
    References
    Comments ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference
    thoc51/thoc5e00906 and homozygous thoc51 mutant testes contain primary spermatocytes but lack post-meiotic cells. thoc51 mutant spermatocytes show abnormally strong condensation of three major bivalent chromosomes and the phase-dark structure of the nucleolus is severely disorganised. thoc51/thoc5e00906 trans-heterozygotes are male sterile.
    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Expression of Mmus\Thoc5Scer\UAS.cMa under the control of Scer\GAL4da.G32 partially rescues the mutant testis phenotypes. Nucleolar structure is restored to normal. Chromosome condensation is much similar to wild-type, although chromosome shape appear somewhat abnormal. Elongating spermatid flagella are observed.
    Complementation and Rescue Data
    Rescued by
    Comments
    thoc5+t7.9 rescues the meiotic arrest phenotype of thoc51.
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (1)