General Information
Symbol
Dmel\Toll-9KO
Species
D. melanogaster
Name
FlyBase ID
FBal0258379
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
complex substitution
Comment:
The region from 852 bp upstream of the Toll-9 ATG to 41 bp after the Toll-9 stop codon has been deleted and replaced with a w+mW.hs marker by homologous recombination.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
The genomic region from 852bp upstream of the Toll-9 ATG to 41bp downstream of the Toll-9 stop codon has been replaced by a w+mW.hs marker.
Insertion components
TI{TI}Toll-9KO
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Model Data
Disease Ontology
Models ( 0 )
Disease
Evidence
References
Interactions ( 0 )
Disease
Interaction
References
Comments ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Toll-9KO mutants exhibit partial embryonic lethality, a delay in emergence from eclosion, and reduced lifespan. Embryonic hematopoiesis is not affected in Toll-9KO mutants, indeed the number of larval hemocytes is slightly increased in Toll-9KO mutants. Toll-9KO mutant flies resist clean injury and septic injuries performed with either Gram-positive or Gram-negative bacteria just as well as control flies. The numbers of intestinal stem cells and young enterocytes are similar in unaffected Toll-9KO mutants and control guts. Upon infection, the epithelium renewal occurs normally in Toll-9KO mutant midguts.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Toll-9KO
Name Synonyms
Secondary FlyBase IDs
    References (1)