General Information
Symbol
Dmel\olf186-Fk11505
Species
D. melanogaster
Name
FlyBase ID
FBal0064167
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
P{lacW}olf186-Fk11505
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Model Data
Disease Ontology
Models ( 0 )
Disease
Evidence
References
Interactions ( 0 )
Disease
Interaction
References
Comments ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Introduction of a single copy of olf186-Fk11505 suppresses the cold-sensitive lethality found in Itp-r83Aka1091/Itp-r83Aug3 mutants at 17.5[o]C. The wing posture defect found in these mutants when grown at 25[o]C is also suppressed to a significant extent. The presence of a single copy of olf186-Fk11505 in Itp-r83Aka1091/Itp-r83Aug3 mutants restores flight initiation in response to an air puff and suppresses hyperactivity of flight neuromuscular junctions. Ca-P60AKum170/olf186-Fk11505; Itp-r83Aka1091/Itp-r83Aug3 flies exhibit normal wings and normal levels of spontaneous electrical activity in DLM recordings. Flight ability is restored in a significant number of these triple mutant flies. This is in contrast to the complete loss of flight ability in Itp-r83Aka1091/Itp-r83Aug3 mutants and in olf186-Fk11505/+; Itp-r83Aka1091/Itp-r83Aug3 mutants. Over 60% of olf186-Fk11505/Ca-P60AKum170; Itp-r83Aka1091/Itp-r83Aug3 adults pass as 'fliers' in the cylinder drop test assay. Air-puff delivery elicited sustainable rhythmic flight patterns similar to wild-type in a high proportion of these flies.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Symbol Synonym
l(2)k11505k11505
olf186-Fk11505
Name Synonyms
Secondary FlyBase IDs
    References (3)